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Effects on maternal bone were observed in pregnant and lactating rats in a pre- and postnatal toxicity study when esomeprazole magnesium was administered at oral doses of 14 to 280 mg/kg/day (about 3.4 to 68 times an oral human dose of 40 mg on a body surface area basis)

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Using either a mast cell stabilizer or a medication to reduce prostaglandin E2 synthesis (e.g., a COX2 inhibitor) stopped the hypersensitivity in the animal model of IBS.[ref] In the Lifehacks section (below), youll find a more comprehensive list of substances that also trigger mast cell degranulation

Additional research is exploring its role in vascularization processes and recovery pathways following tissue stress or injury