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10.1073/pnas.0601945103 229 RogersC

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BCL6 functions by repressing a network of genes involved in DNA damage response (p53 and ATR), cell cycle regulation (CDKN1A), B cell activation (CD69 and CD80), and plasma cell differentiation (PRDM1)

The cells recognize circulating iron-loaded Tf via the ubiquitous transferrin receptor 1 (TfR1), which has a high affinity for ferric Tf (Wang et al., 2019[445]), and the Fe 2 -Tf-TfR1 complex is internalized into cells via endocytosis (Mayle et al., 2012[299])

Anders ( Guttiferae )

Although this recycling prolongs the residence time of flavonoids in the body, it is often accompanied by reduced bioactivity, posing challenges for maintaining consistent pharmacological activity