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Heart 107, 150158

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Sub-optimal thyroid function could therefore be a factor in many more conditions than is currently realised, and should be considered particularly in patients who do not respond well to interventions for other conditions

Apoptosis mainly works in synergy through the mitochondrial pathway (the upregulation of Bax/Bak and downregulation of Bcl-2 expressions leading to cytochrome C release), the death receptor pathway (the activation of caspase-8 mediated by Fas/FasL), and the ERS pathway (the inhibition of anti-apoptotic protein expression by the PKR-like endoplasmic reticulum kinase-C/EBP homologous protein (PERK-CHOP) pathway (Wang et al., 2022b

In addition, the deletion of one or more glutathione peroxidase (Gpx) genes, specifically Gpx1Gpx3, has been linked to increased vulnerability to cancer in mice (Chu et al