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Despite these pre-clinical data, the effects of BH4 and related molecules on cardiovascular morbidity and mortality remain unknown, although the possibility of an improved cardiovascular prognosis due to folate supplementation has been definitively ruled out by several randomized controlled trials (Bazzano et al., Instead of preventing NO degradation through reducing oxidative stress, it may be possible to provide exogenous NO via administering NO-donating substances, such as organic nitrates

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The heading of cardiac included patients with diagnosis and having been medically treated for hypertension (HTN), hypercholesterolemia, arrhythmia, congestive heart failure (CHF) or had a history of myocardial infarction (MI)

While plant tryptophan synthase inhibitors with sub-micromolar potency (Sachpatzidis et al., 1999) were predicted to be useful against TB, none have been tested as TrpAB inhibitors in the pathogen (Dias et al., 2009b), whereas many inhibitors for TrpE are known