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2022 Although N isoforms can also act as dominant-negative inhibitors of the full-length proteins and promote tumorigenesis in cells containing wild-type p53 and TAp73 13 in contrast to p53, mice lacking p73 show no increased susceptibility to spontaneous tumorigenesis

In contrast, CC-site mutants P121E_P124G and F80A only modestly reduced Src activation relative to WT

Choosing the optimal assay for determining the protein concentration in your sample will affect the overall success of your research