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Appetite & satiety: Dual GLP-1 + amylin signalling is reported to reduce appetite and increase satiety in trial subjects

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"Nonetheless, our findings suggest that strengthening oversight and aligning incentives for timely reporting of results from clinical trials outlined in postmarketing requirements and commitments may be necessary to ensure postapproval evidence fulfills its intended role in promoting evidence-based clinical decision-making." JAMA

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This triple-agonist approach creates metabolic effects that exceed what any single or dual-receptor compound achieves alone

The changes from baseline sUA concentrationtime profiles following a single dose of lesinurad 200 mg or 400 mg in subjects with various degrees of renal function are shown in Figure 3