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Glutamine synthetase (GS) can maintain the phenotype of M2 macrophages, and the inhibition of GS skews M2-polarized macrophages toward the M1-like phenotype [27]

doi: 10.1038/bjc.2017.323 49 LiZ.LiJ.MoB.HuC.LiuH.QiH.et al

This mechanism lets sirtuins take part in many body processes

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Cell Syst (2018) 6(3):282300.e2

A retrospective off-label chart review study reported that treatment with belimumab led to significantly lower epidermal growth factor (EGF) concentrations [46], although the role of EGF in the pathogenesis or development of pSS remains elusive