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the gene therapy vectors are preferably formulated in a pharmaceutical composition comprising a suitable pharmaceutical carrier as defined below

After exposure to oxidative stimuli, Nrf2 dissociates from Keap1, its negative regulator, and translocates into the nucleus where it heterodimerizes with small Maf proteins [77] and binds to antioxidant responsive element (ARE) sequences, triggering a cytoprotective adaptative response

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