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The results showed a downregulated level of GSH in FA injection, and this effect was blocked by LA supplementation, consistent with the level of xCT, as shown in Figure 6

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Garg BJ, Saraswat A, Bhatia A, Katare OP

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In addition to the traditional perforingranzyme and FasFas ligand cell death induction pathways, interferon- secreted by CD8+ T cells activated in antiPD-L1 therapy can down-regulate System X c expression to reduce cystine uptake and induce ferroptosis (152)