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Cells were treated with LPS as LPS increases protein transcription, translation and secretion, thereby increasing the concentration of secreted proteins

Other IL cytokines and their receptors have been studied as the potential target: IL-17 inhibitor (Secukinumab) was finished in a phase III study displaying improvement in patients with active RA who had an inadequate response to TNF inhibitors

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Tretinoin, also known as retinoic acid, is a form of vitamin A with decades of clinical use in dermatology

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