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control, APAP (received 300 mg/kg APAP), NAC (received 600 mg/kg NAC) and APAP+ NAC groups that received simultaneously 300 mg/kg APAP with 200600 mg/kg NAC (AN200, AN400, AN600)

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Prolonged or repeated exposure to MDMA can lead to long-term abnormalities in the serotonergic system, including decreased levels of serotonin (5-HT) and its major metabolites in the thalamus, striatum, and cortex

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