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In unclear cases, methylmalonic acid and homocysteine levels may be measured

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Efforts to develop oral peptide formulations continue, but success has been limited

Pemetrexed, a clinically applied multi-target antifolate cytotoxic chemotherapeutic drug, has been effective in treating breast cancer and metastatic breast cancer patients previously treated with anthracycline or taxane, with lower toxicity levels (Zhou et al., 2015)

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