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A deficiency of cobalamin can impair DNA and RNA synthesis, therefore, causing homocysteine to accumulate at the expense of methionine

4A, Fig

Oxidative stress, toxicology, and pharmacology of CYP2E1

The general view that most amino acid transporters have indeed been identified, was supported in this study by a complete deconvolution of amino acid transport in two cell lines of very different origin, namely, lung and brain

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Further research is required to investigate the targeted cell types and specific stages of the disease process in which lactylation plays a role in AD (Fig