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Additionally, for various pathological conditions, including neurodegeneration, lysosomal and autophagy dysfunction occur concomitantly and both contribute to the disease progression [38,39], further supporting the close connection between lysosomal dysfunction and autophagy inhibition

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IDH1 is a cytosolic enzyme that metabolizes isocitrate to -KG to generate cytosolic NADPH

To date, several studies have investigated the association between vitamin E intake and vitamin E levels in body fluids and neurodegenerative diseases, including PD

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