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Under normal conditions, oxidative and metabolic stress in the CNS remain low (Almeida et al., 2004)

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Aside from SQ109, several inhibitors of MmpL3, including AU1235, ICA38, Rimonabant, NITD-349, and SPIRO, have shown a strong bactericidal ability against Mtb , and have been proven to target MmpL3 [117, 125, 128, 135]

Second, NK cells target upregulated NKG2D ligands on melanocytes (such as MHC class I-related protein A), triggering cytotoxic responses (83)