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Description

Neoplasia (2012) 14(10):91525

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Unlike normal cells, which rely primarily on oxidative phosphorylation for energy production, most tumor cells preferentially utilize aerobic glycolysis (the Warburg effect) to convert large amounts of glucose into lactate and export it from the cell, even under conditions of a sufficient oxygen supply [18]

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Biochemically, these failures manifest as enlarged and degenerated mitochondria with loss of cristae, driving pathological cardiac remodeling [144]

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