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M., Pean, A., Vickers, C

doi: 10.19080/CTBEB.2018.13.555871 20 BellantiF.Lo BuglioA.VendemialeG

These processes tend to increase water solubility of the drug and can generate metabolites that are more chemically active and/or potentially toxic

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In our previous rat kainate model, one-week SAR treatment (25 mg/kg, oral gavage) twice a day for the first three days followed by a single dose in the next four days (1-week treatment) significantly reduced spontaneous seizures, neuroinflammation, and neurodegeneration in a four-month rat study [103]

50 Varying degrees of compensatory expression of the PK isozyme normally expressed in leukocytes, PK-M2, in PK-R-deficient erythrocytes appears to influence the clinical severity of PKD as well