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Volcano plots showed 478 metabolites were significantly reduced while 294 metabolites were significantly increased in acute (A) COVID-19 patients compared to HCs ( Figure 2E )

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Notwithstanding the copious experimental evidence correlating the formation of A with cytotoxic effects that may advance the development of NDDs [6871], the detection of A in cognitively normal individuals presents unresolved questions on the nature and function of A oligomeric assemblies that inevitably increase with the aging process [7277]