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This alteration suppressed GATA3 expression via the bile acid-Takeda G protein-coupled receptor 5(TGR5)-cyclic adenosine monophosphate (cAMP) signaling pathway, leading to a marked ~90% reduction in IL-22 secretion from intestinal group 3 innate lymphoid cells (ILC3s), which subsequently induced insulin resistance, ovarian dysfunction (characterized by increased follicular cysts and decreased corpora lutea), and impaired fertility (82)

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Berberine in high glucose-induced podocytes inhibits ROS production, promotes GSH generation, upregulates the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GPX4, and podocin, and decreases the levels of cyclooxygenase 2 and ACSL4

Intranasal delivery of stem cell-based therapies for the treatment of brain malignancies

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Supports Exercise Recovery: May reduce muscle soreness and improve recovery times post-workout