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Twice subacute MPTP administrations induced time-dependent dopaminergic neurodegeneration and inflammation in midbrain and ileum, as well as gut microbiota disorders in PD mice

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The A53T mutation in the -synuclein gene ( SNCA A53T , or A53T) is one of the key missense gene mutations linked to early onset familial PD, as the mutated -synuclein variant is prone to self-aggregation (12)