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(Source: Phlebotonics for venous insufficiency)

Crocin: A fighter against inflammation and pain

The EMAs LOS encourages further nonclinical and exploratory clinical analyses to evaluate the translational relevance of changes in identified nonclinical DIVI biomarkers. The FDAs LOS encourages additional use of these biomarkers to characterize their potential role for monitoring DIVI in early clinical drug development. Although not qualified by FDA or EMA, these translatable biomarkers, alone or in panel(s), are anticipated to reflect DIVI affecting vascular smooth muscle cells and endothelial cells, as well as the associated inflammatory response, as determined by histopathologic endpoints in rodents

Rajman et al., 2018

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In addition, the oxidative damage induced by excessive ROS and decreases in antioxidants, such as superoxide dismutase and glutathione peroxidase in diabetes also causes mitochondrial dysfunction (63)