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Earlier biguanides such as phenformin and buformin showed greater potency but were withdrawn from the market due to a high incidence of lactic acidosis (LaMoia and Shulman, 2021)

doi: 10.2165/00003495-198938040-00003 14 BrownE

The NanoClick assay 22 determines permeability of azide-labeled peptides by combining intracellular copper-free click chemistry with NanoBRET technology

Neuron 105 , 855866.e855 (2020)

This suggests an ancient underlying mechanism for detecting the ratio of these three amino acids

Moreover, loss of DJ-1 impairs microglial function through heightened inflammatory response to -syn, reduced -syn uptake due to lipid raft disruption, and defective autophagy-lysosomal degradation (Nash et al., 2017)