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With a little fabrication, we made it happen

Methionine is less hydrophobic than valine and therefore substitution to methionine should have lessened the aggregation propensity

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Ethics declarations Ethics and consent to participate The animal research procedures were approved by The First Peoples Hospital of Lianyung, lianyungang (Ethics approval number: : IACUC20250611 (R11) and carried out in accordance with the Guide for the Care and Use of Laboratory Animals (Ministry of Science and Technology of China, 2006)

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