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Extracellular -crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria

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Mechanistically, the VEGF-C signaling pathway induces CCL21 expression in LECs, subsequently enhancing the infiltration of CCR7+ nave T cells and DCs to the tumors (100)

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Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS