glutathione levels and autism The Ambiguous Role of Growth Factors in Autism: What Do We Really Know? Evidence of oxidative damage and

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According to the Global Burden of Disease 2021 study, IS ranks as the second leading cause of death worldwide and remains a major cause of long-term disability ( Disruption of the bloodbrain barrier (BBB) is a key pathological feature of IS, primarily caused by degradation of tight junction (TJ) proteins and increased transcytosis, leading to vascular hyperpermeability ( The BBB is a specialized neurovascular interface that regulates molecular and ionic exchange between the systemic circulation and the central nervous system (CNS), thereby maintaining cerebral homeostasis (25)

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Both hypomethylation (COVID-19, POTS, 1298C/677T, FM, and CFS) and hypermethylation (LC, 677TT) increase Hcy

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