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This study highlights crocin as a promising candidate for SCA3 therapy and provides a foundation for future experimental validation

Our findings suggest that interventions targeting immunometabolism and oxidative stress could offer novel therapeutic avenues for cancer and aging-related diseases

Although HMP is useful for organ preservation, it is difficult to assess organ viability during HMP because of the reduced metabolic activity at low temperatures, and the adoption of HMP has faced logistical challenges

Relationship to lipid peroxidation

Modes of transmission include mitochondrial, X-linked, autosomal recessive, an unusual mixed mitochondrial and autosomal recessive form, and other undefined pathways

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