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In this regard, EPOP is projected to impair PRC2.1 PHF19 or PRC2.1 MTF2 chromatin targeting by displacing the DS helix, unlocking the stabilized dimer, and thereby promoting the structural transition from the dimeric state into the monomeric state (Fig

It was found that the Sonic Hedgehog (SHH) signaling pathway may mediate RA-through mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) signaling pathway by regulate proliferation and migration of FLSs, which are involved in the development of RA