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Intracellular GSH is released into the extracellular space via multidrug-resistant protein 1-mediated transporter (19)

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Interestingly, the levels of dUMP accumulation reduced over the 72 h despite continued TS inhibition, suggesting that there is rebalancing of the nucleotide pools to resolve stress

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3 Mechanistic insights into the impact of heavy metals on ischemic stroke 3.1 Heavy metals and oxidative stress in ischemic stroke Heavy metals disrupt cellular redox homeostasis through multiple interconnected molecular mechanisms, synergistically inducing oxidative stress and neurotoxicity (Figure 2)

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