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Differences in results are due to a combination of factors including ascorbic acid-related concerns (doses, administration routes, plasmatic levels, metabolites recording, and source), cancer characteristics (specific mutations present, type and grade of cancer, received conventional anti-cancer therapy), and individual characteristics (diet, behaviors, genetics, transporters)

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Figure 5 Contrary to the results obtained after modification in the C-terminal of Ang IV where essentially all compounds examined exhibited some activity, oxidative cyclization of the side chains of Cys 1 and Cys 3 and consequently creation of an 11-membered disulfide macrocycle in the N-terminal rendered the inactive compound 20 (Figure 6)