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Data extraction and study outcomes Four reliable authors/reviewers performed the data extraction in a well-defined excel sheet, the excel sheet items were categorized as: general information about the study designs, participants, and intervention, baseline information about certain parameters in the study as: Age, sex, heart rate, and systolic blood pressure, enzymes as malondialdehyde (MDA) and total antioxidant capacity (TAC), cardiac enzymes as creatine kinase MB (CKMB), and the outcome information including mortality rate, and the need for mechanical ventilation and hospitalization time

Behavioral assessments were performed using the elevated plus maze, open field, lightdark box, and hole board tests

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doi: 10.1016/j.jnutbio.2020.108353 31 DinalloV.MarafiniI.FuscoD

The prepared topical formulation exhibited prolonged drug release patterns ( 6.4 Transfersomes Transfersomes are biocompatible vesicular nanocarriers with high deformability potential that are composed of lipids bilayer and membrane softeners ( The incorporation of niacinamide into the transfersomes was accompanied by enhanced skin permeation and improved depigmenting efficacy in comparison to the conventional liposomal niacinamide formulation (Lee et al., 2016b)

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