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In a study by Cao et al., selenium deficiency severely compromised bone microarchitecture as a result of increased bone resorption 66

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doi: 10.1074/jbc.M110.196261 53 OokhtensM.KaplowitzN

The sensitive peptide-bound sp 2 carbonyl group in the transition state is converted into a sp 3 secondary alcohol within the gem-diol intermediate, ultimately leading to peptide bond loss during this transitional phase (Fig

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