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A study examining subjects with impaired glucose metabolism unearthed a significantly increased risk of RLS in this population

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Biophysical and cryo-EM studies have revealed that METTL17 contains a highly labile [4Fe-4S] cluster- essential for its interaction with the mt-SSU and overall structural stabilization 73,82

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In certain embodiments, a responder may be considered as a subject for which treatment as described herein provides equal to or more than about 2 points, or about 1 standard deviation, in the VABS-II composite scores