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CrossRef Non-Invasive Liver Fibrosis Scores Are Associated With Contrast-Associated Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention Hao-Ming He, Chen He, Zhe-Bin You, Si-Cheng Zhang, Xue-Qin Lin, Man-Qing Luo, Mao-Qing Lin, Li-Wei Zhang, Kai-Yang Lin, Yan-Song Guo Angiology .2023

The AMPK pathway becomes active in response to insufficient cellular ATP levels which then leads to mTORC1 inhibition and diminished glutamine transporter expression

Taken together, these studies demonstrate that alterations in the gut microbiome and its metabolic products are consistently associated with immune dysregulation and symptom severity in CFS/ME, suggesting that targeting the microbiome may offer promising new avenues for diagnosis and treatment

So, like think of dungeons and Dragons and final fantasy

I would set the expectation that by one month you should start to see subtle positive changes (maybe your dog sleeps through the night a bit more, or is less disoriented at dusk), and by two to three months the changes should be more pronounced (like a definite reduction in frequency or severity of cognitive episodes)

Accordingly, this evidence has generated a new dogma in the pathophysiology of IBS