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4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release

They uncovered a new type of cell death, whereby mitochondria move to the plasma membrane generating ROS, which in turn damages the plasma membrane leading to cell lysis, the type of lysis being termed mitoxyperilysis (Fig

Glutathione is an anti-oxidant thats naturally synthesised in our body

The transit of orally administered GSH to tissues is thought to occur via absorption from the intestinal lumen, export from enterocytes into the blood, and uptake from the plasma into cells

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Delivery-mediated exosomal therapeutics in ischemia-reperfusion injury: advances, mechanisms, and future directions