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7 According to the country where the headquarter of the research and development unit is located, these vaccines were either jointly developed by multiple countries, accounting for 13 vaccines, or independently developed by a single country, accounting for 65 vaccines (Table 2)

MPP + treatment significantly reduces TIGAR expression in HT22 cells, downregulates NADPH, GPX4, and GSH levels, upregulates GSSG levels and the GSSG/GSH ratio, decreases adenosine triphosphate (ATP) production, and promotes neuronal ferroptosis, iron-dependent lipid peroxidation, and mitochondrial dysfunction, thereby exacerbating neuronal cytotoxicity

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In addition to this, animal research are also incorporated in the literature (561, 562)

During the synthesis of glutathione, supplies of L-cysteine for glutathione synthesis become limiting and homocysteine is diverted into the transsulfuration pathway forming cystathione

In dieronderzoek is vastgesteld dat curcumine opregulatie van UPP (en daarmee spieratrofie) tegengaat door remming van p38 (een MAPK).(112) Bij bedlegerigheid of immobiliteit nemen spierkracht en spiermassa mede af door daling van de activiteit van Grp94 (glucose-regulated protein 94 kDa) in spierweefsel