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They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)

Prescription GLP-1 and GIP/GLP-1 Peptides Semaglutide (Ozempic, Wegovy) and liraglutide (Saxenda) are FDA-approved and have demonstrated significant weight reduction in large randomized controlled trials

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Many of these are injectable medicines that work on hormonal pathways controlling hunger

(PubMed) Lin J, Lee IM, Cook NR, et al

If you have had weight loss surgery, talk to your doctor about what supplements you should take