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Deformed spinal curvature Respiratory deficit Learning disabilities Seizures and vision problems Specification : Inherited in Autosomal dominant pattern Age of Onset : Adolescent to middle age Causes : There are two types : LGMD1 caused due to Autosomal dominant inheritance LGMD2 caused to Autosomal recessive inheritance Symptoms : The unifying features of LGMD are the weakness and atrophy of the voluntary limb-girdle muscles Waddling gait In few cases cardiomyopathy and cardiac arrhythmias is noticed Specification : Third most common type of muscular dystrophy Age of Onset : Before the age of 20 Causes : FSHD 1 and FSHD2 are caused by genetic mutations or faulty expressions of some genes

305 N-Acetylgalactosamine (GalNAc) Most approved products based on bio-conjugated delivery systems use the GalNAc-coupled delivery system developed by Alnylam Pharmaceuticals

Those compounds primarily target GLP-1 receptors

Intuitively, GPx4, a hydroperoxide scavenger responsible for converting lipid hydroperoxides into non-toxic lipid alcohols [64, 65], effectively suppresses lipid hydroperoxides, including phospholipids, fatty acids as well as cholesterols, decreases vascular endothelial cell damage to oxidized lipids, and inhibits AS development

10.3390/metabo10110469 6 ArakawaT.Kobayashi-YurugiT.AlguelY.IwanariH.HataeH.IwataM.et al (2015)

rat or mouse, the disease subtype of Diabetes mellitus (DM), the number of animals in this study utilized as the control group and the experimental or the DCM group, the dose, route of administration and the number of consecutive days the STZ was injected, the blood sugar cutoff point which confirms that diabetes was induced, the gender, age and bodyweight of the rodent species, and the primary outcomes reported by each included study are described in this table (Table 4)