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Dynamin-related protein 1 (Drp1) phosphorylation increases 3.1-fold, promoting excessive mitochondrial fission and compromising sperm motility ( 3.3.2 Energy metabolism impairment 3.3.2.1 Electron transport chain dysfunction EED exposure severely compromises mitochondrial energy production through direct effects on the electron transport chain

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Naisbitt, Dean J

J Cell Physiol 224:7183

These findings suggest that strategies aimed at mitigating ferroptosis, such as activating and upregulating the GPX4 pathway, may offer promising therapeutic avenues for ALS (Wang et al., 2022)

A study conducted on guinea pigs susceptible to osteoporosis, which were placed on a diet low in iron, revealed that lower systemic iron levels delayed the development of cartilage damage