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Structural analysis Figure 2a presents the X-ray diffraction (XRD) pattern of the synthesized AP-AgNPs, exhibiting distinct and well-defined diffraction peaks at 2 = 37.90, 43.99, 64.29, and 77.20, which correspond to the (111), (200), (220), and (311) crystallographic planes, respectively

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By activating RAGE/TLR4NF-B and suppressing the Nrf2GPX4/SLC7A11 pathway, HMGB1 establishes a feedforward loop that amplifies inflammation and ferroptosis in AKI ( TACSTD2 in renal tissues enhanced ferroptosis cell death and tubular damage via HMGB1-dependent TLR4/NF-B activation (Tang et al., 2021)