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Semin Neurol 10:4245 Lojo N, Rasic Z, Zenko Sever A et al (2016) Effects of diclofenac, l-NAME, l-Arginine, and pentadecapeptide BPC 157 on gastrointestinal, liver, and brain lesions, failed anastomosis, and intestinal adaptation deterioration in 24 hour-short-bowel rats

Since uremic animals also failed to show increases in GFR and RPF after amino acid infusion, known to enhance kidney function in healthy animals, the authors concluded that the vasodilatory eicosanoids are already maximally stimulated under baseline conditions in uremic animals and, consequently, renal reserve capacity is diminished in these animals

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