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While the activity of JasF remains to be reconstituted, the domain architecture of JasF resembles that of FAD-containing NAD(P)H-dependent oxidoreductases reminiscent of single component marine tryptophan brominases Bmp5 and AetF wherein the flavin reductase and halide oxidase domains are fused into a single polypeptide [36, 37]

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2, 6 Mandatory folic acid fortification of foods (i.e