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Common reasons for deprescribing include No active indication (e.g., health condition resolved) New or worsening condition Potential risks outweigh anticipated benefits Preventive indication with life-limiting conditions Lack of benefit or ineffectiveness Result of a prescribing cascade Nonadherence Interactions or ADEs Prescribers and pharmacists can use the available prescribing and deprescribing clinical tools, but they must also review all medications and assess the benefit versus risk for individualized patients

P -value of less than 0.05 was considered statistically significant

doi:10.1073/pnas.1215689109

For instance, mutations in mtDNA encoding complex I subunits, which impact the CoQ10 binding pocket, are associated with Lebers hereditary optic neuropathy

pQC mKorange IX was a gift from Connie Cepko (Addgene plasmid # 37344), previously modified by replacing the mKO2 coding sequence with an empty MCS 7 , generating pQC MCS IRES Puro (Addgene # 110343) and pQC V5 MCS IRES Puro (Addgene # 110342)

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