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It is primarily caused by chronic Helicobacter pylori infection (Vaqar S, 2023)

Here, 337 participants from 7 centers were included, with 304 participants providing paired capillary DPS or DBS and venous plasma samples

Increased risk of inconsistent results for RCTs suggests higher prevalence of bias, which may arise due to many issues including design bias, conflicts of interest, treatment differences by physicians aware of allocation, attrition bias, ascertainment bias, randomization failures, errors, or fraud

Nemluvio also significantly alleviated itch and reduced sleep disturbances as compared with placebo