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Given the rich lipid content of the nervous system, hemoglobin-derived iron works with lipid peroxidation to induce ferroptosis, which eventually leads to neuronal mitochondrial damage, edema, and apoptosis of neurons and astrocytes

Finally, the FOT values were calculated for all samples and used in all subsequent quantitative analyses to correct sample loading differences

A higher dosage can cause life-threatening health issues including renal failure or blood poisoning, which is why several nations have outlawed its usage

doi: 10.1097/00000542-200207000-00030 110 TsaiCSTsaiYTLinCYLinTCHuangGSHongGJet al

The mice were pre-loaded with 500 mg/kg IVIg (privigen, CLS Behring) via i.v

Crit Rev Biochem Mol Biol 48(2):173181