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Aside from phototherapy and steroid treatment, alternative treatments that target antioxidant activity in vitro and/or in vivo are emerging [103]

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however, no differences were observed in T3, T4, or TSH levels.31 An increased risk of osteopeniaup to fourfold higherhas been reported in patients with PG vs individuals without gray hair.32 Nevertheless, more recent studies failed to confirm this association.33 In cases of PG, a laboratory work-up may be necessary, including iron studies, vitamin B12, folic acid, 25-hydroxyvitamin D, thyroid profile, and antithyroid antibodies.3133 Clinical features Gray hair primarily results from an optical phenomenon