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CB-839 is the most advanced GLS1 inhibitor currently in clinical practice and has been shown to effectively inhibit tumor proliferation (102)

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(7) Ogru E, Wilson J C, Heffernan M, Jiang W J, Chalmers D K, Libinaki R, Ng F (2000) The conformational and biological analysis of a cyclic anti-obesity peptide from the C-terminal domain of human growth hormone The Journal of Peptide Research, 2000 Dec, Volume 56 (Issue 6), Pages 388-97

however, the underlying mechanism is incompletely understood

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