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doi: 10.3389/fphar.2022.841818 149 MahjabeenWKhanDAMirzaSA

This clinical study, although prospective, is not a randomized controlled trial

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Development of small molecules designed to activate the HGF/Met system In the 1990s members of our laboratory began testing the effectiveness of angiotensin IV (AngIV) and metabolically stable AngIV analogs to facilitate memory in animal models of AD [Figure 1]

Both entacapone and tolcapone are COMT inhibitors that inhibit catechol-O-methyltransferase