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Description

Mutation frequency consistently increased upon MG exposure compared to the non-treated groups in both growth conditions, but was more pronounced in defined media (Fig 4A and 4B)

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doi: 10.1016/j.redox.2017.01.015 69 KudelaE.LiskovaA.SamecM.KoklesovaL.HolubekovaV.RokosT.et al

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have suggested that elevated expression of SUMO-activating enzyme SAE1/UBA2 in RA-FLSs and synovial tissues promotes joint inflammation through SUMOylation-dependent metabolic reprogramming (27)

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Single-cell RNA sequencing (RNA-seq) has demonstrated that reactive astrocytes exhibit transcriptional diversity, with specific subsets adopting either neuroprotective or neurotoxic phenotypes

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