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Before APAP challenge, IL-1ra KO mice exhibited reduced mRNA expression of these enzymes, compared with WT mice (Figure 2)

FOS can directly modulate the transcription of inflammatory cytokines (such as TNF-, IL-6 and IL-1), and promote the pathogenesis of AKI [65]

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Clinical data on magnesium supplementation in DILI are sparse, and critically, it is unknown whether modulating magnesium homeostasis can improve hard clinical outcomessuch as progression to acute liver failure or mortalityespecially for the many DILI subtypes that are not mediated by APAP-like metabolic activation

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