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doi: 10.1097/FJC.0000000000001046 121 YanCLiT-S

or at least one instance of R 1 Is a group of the formula: wherein L is an optionally substituted alkylene, an optionally substituted alkenylene, an optionally substituted alkynylene, an optionally substituted heteroalkylene, an optionally substituted heteroalkenylene, an optionally substituted heteroalkynylene, an optionally substituted carbocyclylene, an optionally substituted heterocyclylene, an optionally substituted arylene, or an optionally substituted heteroarylene, and R 6 and R 7 Each independently selected from the group consisting of: hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, and a nitrogen protecting group

Magnusson, J.R

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conducted a double-blind, randomized placebo-controlled clinical trial investigating benfotiamine efficacy in treating alcohol dependence

In addition, drug repurposing may be particularly appropriate in conditions with high oxidative stress and comorbidities [110, 111]